Bin3 is a Bin1-related gene discovered by LIMR researchers which encodes an evolutionarily conserved and ubiquitously expressed member of the BAR superfamily, curved membrane and GTPase-binding proteins implicated in signal transduction and vesicular trafficking (1). Research has identified roles for Bin3 in cell division and cancer, where it acts as a tumor suppressor. Bin3 is found in all cells with additional specific isoforms found in the immune system and in the brain.
In humans, Bin3 maps to chromosome 8p21.3, a region widely implicated in cancer suppression that is often deleted in non-Hodgkin's lymphomas and various epithelial tumors (2). A LIMR study in a mouse model suggests that homozygous inactivation of Bin3 causes cataracts and an increased susceptibility to lymphomas during aging (3).
Recombinant full length human Bin3 with a COOH-terminal glutathione S-transferase (GST) fusion tag
Source Antibody/Purification Information
Mouse monoclonal 3A4, isotype IgG2b
Species Cross Reactivity
Human, mouse; others not tested
Western, immunoprecipitation, ELISA
Recommended Dilutions for Each Application
Western - use at an assay dependent dilution
Immunoprecipitation - use at an assay dependent dilution
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