Indoleamine 2,3-dioxygenase 2 (IDO2) is a novel IDO1-related gene discovered and patented by LIMR researchers, and may play a role in T and B cell immunity (Metz et al 2007). Recent studies at LIMR have defined roles for IDO2 in inflammation and autoimmune disease. Emerging evidence postulates that IDO2 and IDO1 function in a common genetic pathway, and that IDO2 is the more evolutionarily ancestral gene. This suggests that it may be more important than IDO1 to human biology and disease. Currently available LIMR antibodies recognize human and mouse proteins (polyclonal) or mouse proteins (monoclonal).

Antigen Information

Complete murine IDO2 protein

Source Antibody/Purification Information

Mouse monoclonal 1HC, isotype IgG
Protein G purified

Species Cross Reactivity

Mouse, not human IDO2; other species have not been tested

Applications

Western, IF, ELISA. IHC testing has been negative. IDO2 is expressed in a few select cell types and levels of protein expression appear to be very low, perhaps below the level of detection by IHC.

1. Metz R, Duhadaway JB, Rust S, Munn DH, Muller AJ, Mautino M, Prendergast GC (2010). Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase. Mol. Cancer Ther. 9(6):1864-71.

To Place an Order

By Phone: 484-476-3474
By Fax: 484-476-8533
By Email: sales@limrdev.com

By Mail:
LIMR Development, Inc.
Sales Department
Attn: J. Wynne
100 East Lancaster Avenue
Wynnewood, PA 19096

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